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Act now · U.S. emergency help

Someone needs help

Call 911 for unresponsiveness, abnormal breathing, seizure, collapse, chest pain or severe overheating with confusion. You do not need to identify the drug.

Call 911 now

Do not wait to identify the substance.

1. Call for emergency help

Call 911. Tell the dispatcher your exact location and what you can see. Put your phone on speaker and follow their instructions. Send someone to guide responders in, if possible.

Blue or gray lips, gurgling or unusual snoring in someone who will not wake can indicate a breathing emergency. Do not wait for every warning sign.

Sources & review notes
  1. 5 Things to Know About Naloxone
    CDC · Published/updated 2024-05-02 · Accessed 2026-09-26 · Recognition, response, repeat doses and access
  2. First aid: Act fast!
    National Capital Poison Center · Accessed 2026-09-26 · 911 criteria and Poison Control contact
  3. Understanding the Dangers of Alcohol Overdose
    NIH / NIAAA · Accessed 2026-09-26 · Signs, combinations, bystander response

2. Check breathing & respond

If unresponsive and not breathing normally, start CPR as directed by the dispatcher; use an AED if available and follow its prompts. Breathing support matters in overdose. Provide rescue breaths if trained and directed.

If unconscious but breathing normally, place the person on their side and continue watching their breathing. Stay until medical help arrives.

Sources & review notes
  1. Opioid-Associated Emergencies
    American Red Cross · Accessed 2026-09-26 · CPR and AED must not be delayed for naloxone
  2. Access to Naloxone Can Save a Life During an Opioid Overdose
    FDA · Accessed 2026-09-26 · Temporary reversal, emergency response, OTC access
  3. Drug use first aid
    NIH / MedlinePlus · Published/updated 2026-04-13 · Accessed 2026-09-26 · First aid and emergency assessment

3. Give naloxone if opioid overdose is possible

Give available naloxone according to the package instructions. If normal breathing does not return, another dose may be needed after 2–3 minutes. Do not delay or interrupt CPR or AED use to give naloxone. Continue dispatcher-directed breathing support. Naloxone does not reverse all drugs, and emergency care is still needed after someone wakes.

Sources & review notes
  1. Opioid-Associated Emergencies
    American Red Cross · Accessed 2026-09-26 · CPR and AED must not be delayed for naloxone
  2. 5 Things to Know About Naloxone
    CDC · Published/updated 2024-05-02 · Accessed 2026-09-26 · Recognition, response, repeat doses and access
  3. Access to Naloxone Can Save a Life During an Opioid Overdose
    FDA · Accessed 2026-09-26 · Temporary reversal, emergency response, OTC access

4. Overheating or a seizure

For severe overheating with confusion, move to a cooler place if safe, remove excess clothing and use cool wet cloths while help is coming. Do not force fluids into someone confused, seizing or unconscious.

During a seizure, clear hazards and cushion the head. Do not restrain the person or put anything in their mouth. Do not give food or drink until fully alert.

Sources & review notes
  1. First Aid for Seizures
    CDC · Published/updated 2024-05-15 · Accessed 2026-09-26 · Injury prevention and actions to avoid
  2. Heat-related Illnesses
    CDC / NIOSH · Accessed 2026-09-26 · Heat stroke first aid

Avoid home remedies

Do not induce vomiting or give more drugs. Coffee, cold showers and walking do not reverse alcohol overdose. Preserve known packaging or medication information for responders without delaying help.

Sources & review notes
  1. First aid: Act fast!
    National Capital Poison Center · Accessed 2026-09-26 · 911 criteria and Poison Control contact
  2. Drug use first aid
    NIH / MedlinePlus · Published/updated 2026-04-13 · Accessed 2026-09-26 · First aid and emergency assessment
  3. Understanding the Dangers of Alcohol Overdose
    NIH / NIAAA · Accessed 2026-09-26 · Signs, combinations, bystander response

Known substance?

The general steps above still apply. Selecting a substance must not delay calling for help.

At a UA event

At a UA event, alert staff, security, or the medical team immediately. Call 911 for an emergency; event staff do not replace emergency professionals.

Poison Control

For exposure questions when there are no life-threatening symptoms. Do not use this in place of 911 in an emergency.

1-800-222-1222

This resource provides general education, not medical advice or personal clearance to use a substance. No drug or combination is risk-free. For an emergency, call 911.