Substance education
GBL.
Loss of consciousness and depressed breathing can be life-threatening.
Also known as Gamma-butyrolactone. A name does not verify contents.
What it is
GHB depresses the central nervous system. GBL is converted to GHB in the body. Names do not establish product concentration or purity.
Sources & review notes
- The clinical toxicology of GHB, GBL and 1,4-butanediol
Clinical Toxicology · Published/updated 2012 · Accessed 2026-09-26 · Poisoning, metabolism and withdrawal
Sudden deterioration
Hospital cases include coma, vomiting and slow heart rate; some need mechanical breathing support. Appearing asleep is not a reason to wait.
Sources & review notes
- Clinical features of GHB and GBL toxicity and concomitant drug and alcohol use
University Hospital Zurich / Drug and Alcohol Dependence · Published/updated 2005 · Accessed 2026-09-26 · 65 emergency presentations
Alcohol increases risk
A multicenter study found deeper unconsciousness and greater care needs with alcohol co-exposure. Other sedatives add concern; no combination is cleared here.
Sources & review notes
- Clinical relevance of ethanol coingestion in GHB/GBL intoxication
Euro-DEN Plus investigators / Toxicology Letters · Published/updated 2019 · Accessed 2026-09-26 · Alcohol co-exposure and depressed consciousness
Dependence & withdrawal
Withdrawal after repeated use can be severe and life-threatening. Get medical help to plan stopping and manage symptoms.
Sources & review notes
- The clinical toxicology of GHB, GBL and 1,4-butanediol
Clinical Toxicology · Published/updated 2012 · Accessed 2026-09-26 · Poisoning, metabolism and withdrawal
Warning signs
Difficulty waking or abnormal breathing requires 911. Do not rely on an expectation that someone will wake quickly.
Sources & review notes
- First aid: Act fast!
National Capital Poison Center · Accessed 2026-09-26 · 911 criteria and Poison Control contact - Clinical features of GHB and GBL toxicity and concomitant drug and alcohol use
University Hospital Zurich / Drug and Alcohol Dependence · Published/updated 2005 · Accessed 2026-09-26 · 65 emergency presentations
Interaction records
This resource provides general education, not medical advice or personal clearance to use a substance. No drug or combination is risk-free. For an emergency, call 911.