Interaction checker.

Choose two substances to view a sourced interaction record. This is not a complete interaction database or personal medical advice.

High risk

Alcohol + Cocaine

MedlinePlus identifies increased overdose risk when cocaine is used with alcohol or other drugs.

Primary concerns

Cardiovascular toxicity and overdose.

Emergency concerns

Chest pain, seizure or collapse requires 911.

Last source review: 2026-09-26 · source checked

Sources & review notes

Cocaine
NIH / MedlinePlus · Accessed 2026-09-26 · Effects, overdose, treatment
Cocaine intoxication
NIH / MedlinePlus · Published/updated 2025-01-08 · Accessed 2026-09-26 · Severe intoxication and complications

Risk labels describe the cited record, not the safety of a person or a dose. Two-substance records cannot establish the effects of three or more substances. Unknown ingredients and health conditions can change risks.