Underground Alchemy
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Evidence, with limits

Interaction checker.

Choose two substances to view a sourced interaction record. This is not a complete interaction database or personal medical advice.

Severe risk

Alcohol + Prescription opioids

Alcohol can amplify opioid-related sedation and breathing suppression.

Primary concerns

Coma and fatal overdose.

Emergency concerns

Use emergency guidance; naloxone addresses the opioid component.

Last source review: 2026-09-26 · source checked

Sources & review notes
  1. New Safety Measures for Opioid Analgesics and Benzodiazepines
    FDA · Published/updated 2016-08-31 · Accessed 2026-09-26 · Patient information: combined CNS depressants
  2. Understanding the Dangers of Alcohol Overdose
    NIH / NIAAA · Accessed 2026-09-26 · Signs, combinations, bystander response

Risk labels describe the cited record, not the safety of a person or a dose. Two-substance records cannot establish the effects of three or more substances. Unknown ingredients and health conditions can change risks.