Interaction checker.

Choose two substances to view a sourced interaction record. This is not a complete interaction database or personal medical advice.

Severe risk

GBL + Alcohol

Emergency-department data associate this combination with deeper unconsciousness and greater treatment needs.

Primary concerns

Loss of consciousness and breathing compromise.

Emergency concerns

Do not leave an unresponsive person to sleep; call 911.

Last source review: 2026-09-26 · source checked

Sources & review notes

Clinical relevance of ethanol coingestion in GHB/GBL intoxication
Euro-DEN Plus investigators / Toxicology Letters · Published/updated 2019 · Accessed 2026-09-26 · Alcohol co-exposure and depressed consciousness
Clinical features of GHB and GBL toxicity and concomitant drug and alcohol use
University Hospital Zurich / Drug and Alcohol Dependence · Published/updated 2005 · Accessed 2026-09-26 · 65 emergency presentations

Risk labels describe the cited record, not the safety of a person or a dose. Two-substance records cannot establish the effects of three or more substances. Unknown ingredients and health conditions can change risks.