Underground Alchemy
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Evidence, with limits

Interaction checker.

Choose two substances to view a sourced interaction record. This is not a complete interaction database or personal medical advice.

Severe risk

Prescription opioids + Benzodiazepines

FDA warns of serious harm when these medicine classes are combined.

Primary concerns

Extreme sedation and slowed breathing.

Emergency concerns

Call 911 for impaired consciousness or breathing.

Last source review: 2026-09-26 · source checked

Sources & review notes
  1. Boxed Warning updated for benzodiazepines
    FDA · Published/updated 2020-09-23 · Accessed 2026-09-26 · Dependence, withdrawal, alcohol and opioids
  2. New Safety Measures for Opioid Analgesics and Benzodiazepines
    FDA · Published/updated 2016-08-31 · Accessed 2026-09-26 · Patient information: combined CNS depressants

Risk labels describe the cited record, not the safety of a person or a dose. Two-substance records cannot establish the effects of three or more substances. Unknown ingredients and health conditions can change risks.