Interaction checker.

Choose two substances to view a sourced interaction record. This is not a complete interaction database or personal medical advice.

Severe risk

Ketamine + Benzodiazepines

Ketamine and benzodiazepines can produce profound combined sedation.

Primary concerns

Respiratory depression and coma.

Emergency concerns

Follow emergency guidance for reduced consciousness or breathing.

Last source review: 2026-09-26 · source checked

Sources & review notes

KETALAR prescribing information
FDA · Published/updated 2022 · Accessed 2026-09-26 · Warnings, adverse reactions and interactions 7.3

Risk labels describe the cited record, not the safety of a person or a dose. Two-substance records cannot establish the effects of three or more substances. Unknown ingredients and health conditions can change risks.